First Reta Phase III Results

[AndyPanda]

One interesting tidbit about how these studies work in the background, from the patient's point of view, is this comment I found on Reddit from a guy who participated in the study and then decided to silently start skipping doses because he felt he lost too much weight:

View: https://www.reddit.com/r/RetatrutideTrial/comments/1pk86cs/comment/ntkkdgo/

Can’t trust anybody. Guy gets a golden opportunity and says fuck you to the company who gave it to him. I hope they can find out who it is and sue him for violating his contract.

 

[AndyPanda]

I had to look up Dysesthesia to see how it was different than Allodynia. They are so similar that I wonder if you can have a touch of both at the same time.

Allodynia is the experience of pain from stimuli that are not normally painful, while dysesthesia refers to abnormal, often unpleasant sensations that may occur without an external stimulus.

Definitions​

Allodynia : This condition involves experiencing pain from stimuli that typically do not cause pain, such as light touch or mild temperature changes. For example, a person with allodynia may feel pain when their skin is lightly brushed or when they wear clothing.

https://www.bing.com/ck/a?!&&p=78ba...WVuLWFsbG9keW5pYS1hbmQtZHlzZXN0aGVzaWEv&ntb=1

Dysesthesia : Dysesthesia is characterized by abnormal sensations that can be unpleasant or painful. These sensations may include burning, tingling, or a feeling of something crawling on the skin. Dysesthesia can occur spontaneously or in response to stimuli that usually do not provoke such sensations.

In my experience ARA-290 works for Allodynia. A little research shows that’s it can be used to treat dysesthesia as well. It shows promise across the boards with neuropathy and nerve related pain.

 

[Calm Logic]

In my experience ARA-290 works for Allodynia. A little research shows that’s it can be used to treat dysesthesia as well. It shows promise across the boards with neuropathy and nerve related pain.

Pinning ARA-290 today. Standard dose seems to still be 4 mg. Largest vials I have found are 30 mg (made by ZYH and resold at J5 as kits and BioBombshell as singles).

 

[PAPoots]

The allodynia is more annoying than painful. Between the DOMS from going to the gym and the pain from shoveling all this fn snow, I only notice it when I think about it.

Vitamin B works great on fixing it. I just have to remember to take it.

 

[IshimaruKenta]

Pinning ARA-290 today. Standard dose seems to still be 4 mg. Largest vials I have found are 30 mg (made by ZYH and resold at J5 as kits and BioBombshell as singles).

Interesting, I've seen the max at 16mg from PGB. Could you DM me the info please?

 

[Really? 26135]

Interesting that there’s so little difference between weight lost on 9 and 12mg. It would appear we’re finding the max effective therapeutic dosage.

 

[PAPoots]

Interesting that there’s so little difference between weight lost on 9 and 12mg. It would appear we’re finding the max effective therapeutic dosage.

Max effective, or the max safe dose. If you took more and all it did was kill all desire to eat. You'd essentially starve to death. I'm sure when it gets more attending, the stories will come out of people trying to lose more and more beyond what they should. Like anorexia.

 

[HerroYuy]

I haven't decided whether or not to pull the trigger on the switch for sure. For me, once I went beyond 7.5mg, the sides became really difficult to deal with. Most days I struggle to eat 1000 calories. I'll have dinner around 7 or 8p, get up around 5a, drink 12 oz of water, and immediately be nauseously full for the next 3 hours. I would suffer through all of this if it yielded any results, but to watch the scale go up and down the same few pounds week after week, month after month, I just can't do it any more.

I also don't feel the appetite / food noise suppression like I used to. Up through 7.5 mg, I barely wanted to eat anything (this is coming from someone who at 5' 9" at 277# ate 5000-6000 calories a day). And that stopped almost overnight. But after I hit 7.5, that noise started creeping back in - almost feeling compelled to eat something, intentionally overeating when I knew how much I'd be suffering from it, etc.

I might give 15 mg a pin this week (due on Monday) just to see what it's like before I make any further decisions. I'm also a week in on a tesamorelin and CJC1295/Ipa cycle, so I may hold off on any GLP changes until that's complete.

I’ve found taking any type of GH increased my hunger and was offsetting my weightloss. I had to take a break from it to start working back down.

 

[Not_Your_Dad]

I’ve found taking any type of GH increased my hunger and was offsetting my weightloss. I had to take a break from it to start working back down.

Appreciate the input!

I've been in this extended plateau / gain and lose cycle for 8-9 weeks now, long before the GH. I went up 2 lbs this week, although I'm fully aware that may be the GH causing some water retention.

I also don't especially care what the scale says, but I'm not noticing the same changes as I have in the past and I find that alarming.

 

[PopTart]

I am fairly certain this was more of a psychological and sociological effect rather than medical one. I.e. I believe this was the result of patients and their families being shocked to see someone who was obese their whole life suddenly slim down, and so they panicked as a result even though the patients could have continued taking the drug with some weight left to lose.

The inclusion criteria for trial participants was a minimum BMI of 27 and the excess weightloss “dropouts” apparently were those with a lower starting BMI (per Gemini). This makes sense as phase 3 was 20 weeks longer than phase 2.

 

[kimmykat415]

One interesting tidbit about how these studies work in the background, from the patient's point of view, is this comment I found on Reddit from a guy who participated in the study and then decided to silently start skipping doses because he felt he lost too much weight:

Comment
by
u/Mean-Homework1425 from discussion

in
RetatrutideTrial

View: https://www.reddit.com/r/RetatrutideTrial/comments/1pk86cs/comment/ntkkdgo/

Click to expand...

Oh this is very interesting and helpful. Thank you.

I've been on Reta since May but am at my goal weight/size. I have been trying to figure out what maintenance will look like as I attempt to add some muscle back. Even with a slightly lower dose every ten days and holiday indulgences I can tell I'm not eating at maintenance.

 

[domiboy]

I had to look up Dysesthesia to see how it was different than Allodynia. They are so similar that I wonder if you can have a touch of both at the same time.

Allodynia is the experience of pain from stimuli that are not normally painful, while dysesthesia refers to abnormal, often unpleasant sensations that may occur without an external stimulus.

Definitions​

Allodynia : This condition involves experiencing pain from stimuli that typically do not cause pain, such as light touch or mild temperature changes. For example, a person with allodynia may feel pain when their skin is lightly brushed or when they wear clothing.

https://www.bing.com/ck/a?!&&p=78ba...WVuLWFsbG9keW5pYS1hbmQtZHlzZXN0aGVzaWEv&ntb=1

Dysesthesia : Dysesthesia is characterized by abnormal sensations that can be unpleasant or painful. These sensations may include burning, tingling, or a feeling of something crawling on the skin. Dysesthesia can occur spontaneously or in response to stimuli that usually do not provoke such sensations.

Everyday thankful I found this forum. And thankful I found this breakdown.

When I was in the CagriSema trials, I thought I was losing my mind feeling these weird burning and tingling sensations around my ears and face all day. I thought I was either getting sick, maybe sore from the gym, or within moments of having a seizure.

In the trials, I'd bring it up a couple times. But the nurses would tell me that it likely wasn't related. And in fear of being taken off, I just kept pushing it to the back of my mind lol.

This just cleared up so much! Def felt like I had a touch of both...but mostly the Dysesthesia.

On Tirz, I haven't felt any of it - yet.

 

[Chucky]

Since the subject of gastric bypass came up, I thought it might be worth mentioning this:

GLP-1RA and gastric bypass surgery surprisingly work in the exact opposite way to trigger weight loss!

With gastric bypass, there's certainly a strong nudge towards changing habits (via a smaller stomach, band, etc.), but the larger effect is believed to be accomplished by severing the vagus nerve from your stomach (which happens as part of the surgery). With that nerve severed, your stomach is no longer able to directly signal to your brain that you just ate via the GLP-1 pathway. Bariatric surgeons believe that prior to surgery your brain had kind of went haywire in trying to manage satiety based on GLP-1 (and related) signaling so by severing that connection, they're shutting down that "faulty" signal and it sounds like a reasonable story to me.

With GLP-1RA, instead of dropping the signal to zero, you're now maxing it out.

With "With GLP-1RA, instead of dropping the signal to zero, you're now maxing it out." do you mean maxing it out where you're always going to be hungry or maxing it out that you never feel hungry?

 

[tubby]

With "With GLP-1RA, instead of dropping the signal to zero, you're now maxing it out." do you mean maxing it out where you're always going to be hungry or maxing it out that you never feel hungry?

Closer to the second. If it were the first one, then GLP-1RAs would only be prescribed to anorexics.

 

[Leg Show Magazine 4192]

Those are amazing numbers. We are truly living in extraordinary times - GLP-1s, Artificial Intelligence, driverless cars. And I'm glad I'm neither too young nor too old to appreciate all this.

 

[PAPoots]

Those are amazing numbers. We are truly living in extraordinary times - GLP-1s, Artificial Intelligence, driverless cars. And I'm glad I'm neither too young nor too old to appreciate all this.

Your almost covered my entire stock portfolio. Throw space travel inbox that list, and you'd about covered it.