对小剂量药物的强烈反应

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傻瓜

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潜水很久了,第一次发帖。😜

我老婆想试试瑞达(Reta)。我没试过瑞达,也从来没出现过比烦人的打嗝更严重的副作用。我老婆想保守一点,避免出现症状,所以从起始剂量的一半(1毫克)开始。结果她难受得厉害,恶心腹泻持续了四天左右。她开玩笑说,要是一直这样下去,她肯定会瘦下来。有没有人有过类似的瑞达经历,知道这些症状会不会在她身体适应瑞达之后消失?或者,是不是应该试试替扎尼定(Tirz),看看她会不会有同样的反应?
 
在阅读了论坛上的试验和研究后,我发现瑞他莫昔芬(Reta)的大部分益处都从6毫克左右的剂量开始显现,有些人可以耐受更高的起始剂量,而有些人则会出现严重的副作用。因此,我决定从2毫克开始,然后每隔3-4天增加1毫克,直到出现副作用,之后保持该剂量并逐渐增加。第一次注射2毫克后,我没有任何副作用,也没有任何感觉。三天后,我注射了1毫克(开始怀疑我的瑞他莫昔芬是不是假药),也就是第三次注射1毫克(总共4毫克,分7天注射),第二天就出现了严重的副作用,包括恶心、腹泻、打嗝带硫磺味等等。之后,我改为每周注射一次,并保持2毫克两周,然后每隔几周增加1毫克,直到达到6毫克,并一直保持这个剂量一段时间了。现在我没有任何副作用,体重也在稳步下降(每周1-3磅)。
 
我经常在论坛和其他社交媒体上看到有人说瑞达(Reta)的疗效要到中高剂量才能显现。但

我必须澄清,临床试验的结果完全相反,即使从起始剂量开始,哪怕只有1毫克,疗效也能立即显现。

我认为这可能是因为人们的期望值过高,不切实际;也可能是因为他们在开始服用瑞达之前,已经对GLP-1受体激动剂塞玛(Sema)和替拉唑(Tirz)产生了耐受性;又或许这只是集体错觉。我也不知道。

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penewbie said:
I keep reading on the forums and other social media how the benefits of reta begin at the medium to high doses.

I just want to make it clear, the trials completely disagree, with the benefits beginning right away with the starter dose even on just 1mg.

I believe it might be a case of people's expectation being too high and unrealstic, or perhaps they already developed some habituation to glp1 agonism with sema and tirz when they first start reta, or maybe it's just collective delusions. idk.

View attachment 5218
i had benefits right away. less pronounced at 2mg, but moving to 4mg, I began having great results. I didn't get any sides (still don't have many) and trusted the process. i truly don't understand the desire to titrate up quickly. i'm at 7mg now but wish i could have stayed at a lower dose!
 
Maybe you have miss calculated the dosage?

Reta has, for me, no side effects.

Do you have it from a ‘trusted’ source?
 
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