Day 3 of Selank and blown away

[ezdoesit]

Here's the stuff I use for IN Semax, which I like a lot. It's all the same for Selank IN usage as well.

Snoot bottles: https://a.co/d/0jSqHft

Vial pry tool: https://a.co/d/06DP21N

Sterile Saline: https://a.co/d/jlnEonr

IN Calculator: https://peptidescalculator.com/intranasal-calculator

Thank you for this!

 

[yeddie]

I've switched to intranasal for several peps (Semax, Selank, P21, DSIP, Epitalon, etc.) partly because I got tired of being a pincushion. I recon using Hospira BAC saline (purchased from Injection Shop, listed in our vendors section). I use these spray bottles which dose .12 mL per pump. One thing to keep in mind is that you want to avoid sniffing hard when applying. You want the pep to go up into your upper nasal cavity, especially for the nootropic ones that target the brain. Sniffing too hard just sends it down your throat. Tilting your head down helps direct the spray to where you want it.

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[timj382]

Man… thank you so much for this!

I just pull mine out with a syringe. Except that I use sterile saline instead of bac water (and ultimately put the final mix into a sterile, amber nasal-spray bottle), I did the exact same process as with peptides I pin including filtering. I guess if you have the bottle opener gadget, that means I wasted syringes. Would be curious to know how @Chili777 reconstitutes for intranasal.

To just briefly veer off tangentially, I've also taken to using my BPC157/TB500 combo vials intranasally post IN-Selank. And I think it's actually really helping me address some longstanding chronic sinus issues. I guess I should put this in its own thread? But I'd love to know about the experience any others have had with intranasal BPC and/or TB.

 

[Chili777]

I just pull mine out with a syringe. Except that I use sterile saline instead of bac water (and ultimately put the final mix into a sterile, amber nasal-spray bottle), I did the exact same process as with peptides I pin including filtering. I guess if you have the bottle opener gadget, that means I wasted syringes. Would be curious to know how @Chili777 reconstitutes for intranasal.

To just briefly veer off tangentially, I've also taken to using my BPC157/TB500 combo vials intranasally post IN-Selank. And I think it's actually really helping me address some longstanding chronic sinus issues. I guess I should put this in its own thread? But I'd love to know about the experience any others have had with intranasal BPC and/or TB.

My original post on my IN recon process is here: Post in thread 'Selank + Semax--nasal? Effects?' [archived internal link]

I used the same process for Epitalon, Semax and Selank, and the NA versions as well.

I have ongoing sinus issues also. BPC and TB are large molecules, so while they would trouble passing the BBB, they would almost certainly address sinus inflammation topically, so you may be on to something there. TA-1 and KPV have also been used, and I made a combo spray with them, but they are more for viral infections and sinus infections are typically bacterial in nature. My combi spray didn't help much getting rid of the last sinus infection I had.

 

[Yokerr]

I have a question to you...I got mine semax in nasal spray. It's finished now. Is it recommended to use each time a new spray bottle for each portion of semax? Or there is a way to clean the old bottle in a perfect way? How long semax can stay in fridge - reconstitued in NaCl?

 

[Chili777]

I have a question to you...I got mine semax in nasal spray. It's finished now. Is it recommended to use each time a new spray bottle for each portion of semax? Or there is a way to clean the old bottle in a perfect way? How long semax can stay in fridge - reconstitued in NaCl?

You can use alcohol or hydrogen peroxide to clean the bottle and sprayer. I just fill the bottle half way, and spray it a few times to run it through the sprayer, and let it sit for 10 minutes. Then I rinse it out with saline and let it dry. I'm sure you could go crazy if you wanted to with UV light and a clave, but I never had an issue.

I've had sprays last 30 days, refrigerated, and it was clear until the end. I'm still here.

 

[GrandmaJ]

Take a look at Epitalon and Semax, if mild. Nasal sprays for both worked well for my COVID-related brain fog.

Also, Cerebrolysin is the standard, if they would be up for IM injections. P21 with adamantine is also being researched for this, but there are fewer research studies available and none on humans.

Hey Chili-Do you mind sharing your dose protocol for Epi and Semax? How much of each? Do you put them in one inhaler of seperate. Do you use daily or take a break at all.

I also have P21 coming eventually as part of a GB. Excited to try it to see if it helps with my ongoing memory issues.

 

[Chili777]

Hey Chili-Do you mind sharing your dose protocol for Epi and Semax? How much of each? Do you put them in one inhaler of separate. Do you use daily or take a break at all.

I also have P21 coming eventually as part of a GB. Excited to try it to see if it helps with my ongoing memory issues.

Sure. When I use Epitalon IN, I make a 20 mg spray and use 1 mg daily for 20 days until it's gone, usually in the morning. I do the same thing with Semax, but I have used 30 mg to go a month. I have NA Semax available in 30 mg size. Then I have a washout for at least 2 weeks. A month would be better, but 2 weeks seems ok. With Epitalon, I cycle that every 4 months. I do keep them in separate sprayers. They are synergistic, but I usually wait 30-60 minutes between them when running at the same time.

I have P21 coming also, with the Adamantane group for better bioavailability. P21 also lends itself to IN delivery because of its small size. The recommended dosage is 500 mcg - 2 mg. I'll probably start out on the low end, as I usually do. P21 has highly cumulative effects, so I'll go low and slow, for up to six weeks, but at least 4 weeks. There are no human studies, but this one is interesting:

https://www.sciencedirect.com/science/article/pii/S001457931000520X

 

[ussop]

Sure. When I use Epitalon IN, I make a 20 mg spray and use 1 mg daily for 20 days until it's gone, usually in the morning. I do the same thing with Semax, but I have used 30 mg to go a month. I have NA Semax available in 30 mg size. Then I have a washout for at least 2 weeks. A month would be better, but 2 weeks seems ok. With Epitalon, I cycle that every 4 months. I do keep them in separate sprayers. They are synergistic, but I usually wait 30-60 minutes between them when running at the same time.

I have P21 coming also, with the Adamantane group for better bioavailability. P21 also lends itself to IN delivery because of its small size. The recommended dosage is 500 mcg - 2 mg. I'll probably start out on the low end, as I usually do. P21 has highly cumulative effects, so I'll go low and slow, for up to six weeks, but at least 4 weeks. There are no human studies, but this one is interesting:

https://www.sciencedirect.com/science/article/pii/S001457931000520X

I want to try p21 following.

 

[ussop]

Sure. When I use Epitalon IN, I make a 20 mg spray and use 1 mg daily for 20 days until it's gone, usually in the morning. I do the same thing with Semax, but I have used 30 mg to go a month. I have NA Semax available in 30 mg size. Then I have a washout for at least 2 weeks. A month would be better, but 2 weeks seems ok. With Epitalon, I cycle that every 4 months. I do keep them in separate sprayers. They are synergistic, but I usually wait 30-60 minutes between them when running at the same time.

I have P21 coming also, with the Adamantane group for better bioavailability. P21 also lends itself to IN delivery because of its small size. The recommended dosage is 500 mcg - 2 mg. I'll probably start out on the low end, as I usually do. P21 has highly cumulative effects, so I'll go low and slow, for up to six weeks, but at least 4 weeks. There are no human studies, but this one is interesting:

https://www.sciencedirect.com/science/article/pii/S001457931000520X

Thoughts on Ceroxtin ?

 

[DinosaurSoftRocks]

I do love Semax too. Shuts my ADD brain up, more focused etc.

That's what I'm after.... I lay down to sleep and here goes the list of things.....

 

[derekd419]

RS is on day three of research and in our experience this is gaming changing for my subject. They didn’t know they needed it. Apparently they have been in anxiety denial their entire life. A recent major life impact sent them into a spiral and we decided to try it just to see if it would help.

Three days ago we reconstituted 10mg with 10ml sterile saline in a 10ml nasal spray bottle that disburses .1ml per spray.At lunch time RS sprayed in each nostril and within the hour saw a notable shift in mindset. Constant background concerns faded away to a feeling of control and calm. RS will be trying 4 weeks on, 2 off for several cycles.

The past 3 days suggests that if someone has the right brain chemistry, it will have an immediate impact for. After the first day, RS learned they had been conning myself about things in my life. Apparently RS was a bit of an anxiety ridden mess that lied to myself that I was just always ready for the worst case. It was viewed as a good thing rather than a key sign of high anxiety. RS is high functioning and successful so they couldn’t possibly have anxiety, right??? Clearly wrong..

We just started the Peptide journey due to weight.. RS went from GLP1 via local through support via telemedicine. As we read we ended up going grey. After looking over a list of peptides we noticed comments about Selank for anxiety. We never….never…. bought into anxiety, at least in RS’s personal case. They brushed off a lot of signs and some friends suggesting it may be an issue. As we read more about Selank we realized that the people it helped in the Russian studies exhibited very similar symptoms to RS..

The more we read the more we realized RS was an absolute stereotype for anxiety. Every symptom showed could be traced back to childhood. That childhood experience primed RS for extreme anxiety and eventually cardiac issues in midlife despite being otherwise very healthy….weight aside and GLP1 helped dramatically there.

We decided to give it a shot….well a spray as it were. Within hours we noticed a fundamental difference to how RS was reacting. This is already too long so I’ll spare the details. I can only suggest if it has no, or minimal, effect on you then perhaps you are already wired normally and Selank isn’t the path for you.

I am genuinely optimistic for the remodeling effect exhibited in studies at this point, but the peace of mind it has already delivered is unbelievable. We are now looking at the possibility of adding Semax in the future.

so you thinking semax may be helpful for someone who's experienced debilitating panic attacks in the past? I've had bouts of depression as well. I recently just read about semax, as I was mainly getting into peptides for strictly weight loss.

 

[jw717us]

so you thinking semax may be helpful for someone who's experienced debilitating panic attacks in the past? I've had bouts of depression as well. I recently just read about semax, as I was mainly getting into peptides for strictly weight loss.

I've tried the various formulations of each. Semax, NA, and Adamax seem to have zero impact on me whatsoever.

Selank is another matter all together. I've been on it for 5 months now and the impact pretty life changing. I can sit in my own head and just be. I don't need to fill every moment I'm also not focused on solving every problem proactively.