DunningKruger
GLP-1 Enthusiast
You can find plenty of LL-37 studies posted on Peppy’s: some good, some terrifying, and many weakly reported, with unclear methodology, missing dosing context, or poor study design. Google Scholar has more, but you’ll have to dig and read to find balance.jason370 said:
Anecdotally, I recently used LL-37 as part of an illness-prevention stack after being exposed to someone who was clearly sick. I ran 200 mcg daily for 10 days. It was not a miracle shield; I still felt mildly “off” for a couple of days, but I never fully got sick.
The unexpected effect was that my rosacea nearly disappeared by the end of the course. It gave me everything I wanted, but never got, from GHK. I later experimented with using it topically in a tallow balm as well, despite seeing one study claiming LL-37 can contribute to irreversible rosacea-like lesions. That particular study looked poorly constructed to me, so I did not give it much weight on its own.
I would not recommend anyone use LL-37 without first reading several studies and understanding the proposed risks, because the theoretical downsides are not trivial. But personally, I’ll continue to keep it on hand as one tool in a broader prevention stack, alongside mAbs and other more established options.
