Anyone trial >12 mg Reta or stalled on high dose reta?

[rsmith]

Over $33,000 cost of weight loss meds over 5 years. Although, I will probably eat $33,000 worth less food over 5 years so it's essentially a wash

GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review - PMC

Obesity and type 2 diabetes mellitus (T2DM) present major global health challenges, with an increasing prevalence worldwide. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a pivotal treatment option for both conditions, ...

pmc.ncbi.nlm.nih.gov

 

[rsmith]

View attachment 8528

Someone posted the table above in the survo subforum here. I verified most of the KI values before as being what is in the research literature:

WBS

I really hope so, thank you friend Welcome but where can we find the JYC screwup? Didn't see it here or on STG. I screenshot and post I mean it was posted publicly and were looking after our own. If nothing else when was the test performed for jyc? Not sure why there's not an uproar here...

glp1forum.com

But for survo, all I know for sure is the 8:1 ratio between GLP and glucagon was mentioned in the research.

Very different GLP estimates for maz and survo from a different table on TG:

View attachment 8527

It's worth noting again that lower values represent a stronger effect.

https://www.cell.com/cms/10.1016/j.cmet.2022.07.013/attachment/cf8b86fe-d418-481e-a85a-388814d21019/mmc1.pdf

LY3437943 = Reta (look under "Receptor Binding Affinity in Table S1); This is where the Reta values from the table below came from. Table S2 compares Reta (= LY3437943) with Tirzepatide and Semaglutide on their GLP-1, GIP and GCG (Glucagon) potencies (numbers don't match up with tables below because KI values aren't noted for Sema or Tirz).

Above is supplement tables/graphs from this study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00312-6?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S1550413122003126?showall=true

Among other things, the numbers below (assuming they are accurate) suggest that "ghetto reta" has a stronger GLP-1 effect but a weaker glucagon effect compared to straight Reta (so, more appetite suppression but less fat burn for "ghetto reta").

 

[Calm Logic]

I guess maz does relatively well (comparable to survo) despite its least-impressive GLP value since it requires higher doses than survo and the other GLPs.

A great point from The Gospel of @Super Trips is that they are all at least decent for stacking with tirz or reta:

I would stack it with sema, cagri, survo, or maz if you need a boost

im still alive and pooping normal with tirz-reta-cagri current stack

I like survo over sema It was a nice add on with reta and great stacker id say at least 2x stronger than sema

id stack cagri for a month then switch to survo for a month

side effects looking sexy and lean with a gut that was destroyed by glp-1 abuse

pulled over 25mg of tirz in week still eating well and no side effects so whats next???

tried stacking sema works ok but nothing special. Reta or carg next?

imput would be great i cant keep taking Tirz every week like this.

 

[rsmith]

I guess maz does relatively well (comparable to survo) despite its least-impressive GLP value since it requires higher doses than survo and the other GLPs.

A great point from The Gospel of @Super Trips is that they are all at least decent for stacking with tirz or reta:

I guess maz does relatively well (comparable to survo) despite its least-impressive GLP value since it requires higher doses than survo and the other GLPs.

That's actually a good point because the "weaker" agents like Sema and Maz aren't necessarily weaker at higher doses, especially when combined with other agents. I think we're seeing that in big pharma studying higher doses of Sema (e.g., 7 mg.), Sema 5mg. + Cagri 5 mg., Tirz up to 25mg. (approved to go up to 30mg.) and higher "max" Reta as well.

Right now, I'm kind of tinkering with Tirz + Cagri, Tirz + Survo and, eventually, Reta (with and without Cagri or Survo). I'm trying to get an early idea of what works best for maintenance.

There are a slew of new weight-loss agents in the pipeline, some in phase 3 trials so who knows where we'll be in a year from now.

 

[rsmith]

It's worth noting again that lower values represent a stronger effect.

https://www.cell.com/cms/10.1016/j.cmet.2022.07.013/attachment/cf8b86fe-d418-481e-a85a-388814d21019/mmc1.pdf

LY3437943 = Reta (look under "Receptor Binding Affinity in Table S1); This is where the Reta values from the table below came from. Table S2 compares Reta (= LY3437943) with Tirzepatide and Semaglutide on their GLP-1, GIP and GCG (Glucagon) potencies (numbers don't match up with tables below because KI values aren't noted for Sema or Tirz).

Above is supplement tables/graphs from this study: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00312-6?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S1550413122003126?showall=true

Among other things, the numbers below (assuming they are accurate) suggest that "ghetto reta" has a stronger GLP-1 effect but a weaker glucagon effect compared to straight Reta (so, more appetite suppression but less fat burn for "ghetto reta").

View attachment 8552

View attachment 8553

Some added information with citations for some of our favorites... Hat tip to Paupy @ Peppys.